If youre interested in finding an alternative to Zetia, talk with your doctor. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about the change in her physical appearance. However, be sure to take the dosage your doctor prescribes for you. Medications in the fibrate drug class are used to treat high cholesterol. Statins are cholesterol drugs that may be taken with Zetia. The causes of POTS are unknown, but the problem is thought to lie in the communication breakdown between the brain and the cardiovascular system. Chylomicrons help your body, low-density lipoproteins (LDL), sometimes referred to as bad cholesterol, high-density lipoproteins (HDL), sometimes referred to as good cholesterol, triglycerides, which are a type of fat that are building blocks of cholesterol, Apo B (high levels of this protein are a sign of high cholesterol), non-HDL cholesterol (calculated by subtracting your HDL cholesterol level from your total cholesterol), were reduced by an average of 13% to 14% in people who used Zetia, ranged from not changing to being reduced by an average of 1% in people who used a placebo, were reduced by an average of 18% in people who used Zetia, increased by an average of 1% in people who used a placebo, decreased by an average of 13% to 14% in people who used Zetia alone, decreased by an average of 15% to 40% in people who used a statin alone, depending on the statin used, decreased by an average of 24% to 46% in people who used Zetia and a statin, depending on the statin used, ranged from decreasing by an average to 1% to increasing by an average of 4% in people who took a placebo, decreased by an average of 19% to 20% in people who used Zetia alone, decreased by an average of 20% to 54% in people who used a statin alone, depending on the statin used, decreased by an average of 34% to 61% in people who used Zetia and a statin, depending on the statin used. Most patients will need at least 64 to 80 ounces (8 to 10 cups) of hydrating liquids throughout the day, such as water, broth, juice, or decaffeinated tea. Zetia should be protected from moisture and shouldnt be stored in areas where it could get damp or wet, such as bathrooms. Based on animal studies, Zetia may cause harm to the fetus when taken by a pregnant woman. Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. Zetia is meant to be used in combination with a diet thats low in saturated fat and cholesterol. Examples of statin drugs include atorvastatin (Lipitor) and simvastatin (Zocor). For more information, see the How Zetia works section below. Lipitor and Zetia belong to different drug classes. If you think youve taken too much of this drug, call your doctor. The underlying cause is not known, although it sometimes follows bedrest after injury or illness. Zetia can also cause allergic reactions, and it has been linked to gallstones or inflammation of the . Tell your doctor if youre experiencing bothersome side effects from Zetia. But some people have reported memory loss, confusion, and forgetfulness while taking a statin drug. New evidence shows that the drug makers Merck and Schering-Plough have conducted several studies of their popular cholesterol medicine Zetia that raise questions about its risks to the liver, but . You likely wont notice Zetia working in your body. However, excessive alcohol use can damage your liver over time. If you need financial support to pay for Zetia, or if you need help understanding your insurance coverage, help is available. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). To reduce your symptoms in . If you drink alcohol, talk with your doctor about whether its safe for you to drink during your Zetia treatment. It wasnt reported during studies of the drug. Read on to find out more about healthy cholesterol levels, and if a cholesterol level of 250 ml/dL is considered, Heart disease is a top cause of death in the U.S. However, your doctor will check your cholesterol levels about 4 weeks after you start treatment. Here are a few questions to get your discussion started with your doctor: To get information on different conditions and tips for improving your health, subscribe to any of Healthlines newsletters. For this purpose, Zetia is used with a low-cholesterol diet and is taken with atorvastatin or simvastatin in adults and in children ages 10 years and older. POTS is defined by its particular symptoms and an excessive increase in heart rate upon standing. Use these discussion points about familial hypercholesterolemia to prepare for your doctors appointment. Zetia is sometimes used with medications in the statin drug class. The generic is considered to be as safe and effective as the original drug. For more information on the possible side effects of Zetia, talk with your doctor or pharmacist. As with most drugs, some people can have an allergic reaction after taking Zetia. Ways to reduce the symptoms. Brand-name medications usually cost more than generics. Dont take an extra dose to make up for your missed dose. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older: It isnt known how long adults and children experienced muscle pain while taking Zetia with statin drugs in these clinical studies. Some people may develop mild or serious side effects during Zetia treatment. Porphyria patients are often overly sensitive to sunlight. But over time, heavy alcohol use can damage your liver. Talk with your doctor about birth control options that may be best for you. Zetia is available in a strength of 10 milligrams (mg). If you develop liver problems, you may be more likely to experience side effects with Zetia. Watch Part 2 here: https://youtu.be/HPfo2QOa89YHello Friends! Temporary excursions of 59F to 86F (15C to 30C) are allowed. Your doctor may prescribe Zetia with a statin drug. This is a serious medical condition that, if left untreated, can lead to kidney damage. Ezetimibe is used along with a low cholesterol/low fat diet and exercise to help lower cholesterol in the blood. (Primary hyperlipidemia is also called primary high cholesterol.) Both Zetia and Lipitor come as tablets that are swallowed. Total cholesterol is the overall amount of cholesterol found in your blood. Learn about side effects, dosage, and more. You can also call the American Association of Poison Control Centers at 800-222-1222 or use their online tool. diarrhea*. Nexlizet (bempedoic acid/ezetimibe) is a prescription tablet used to lower LDL (bad) cholesterol in certain people. Zetia (ezetimibe) is a prescription drug that treats high cholesterol in adults and children. . Sometimes doctors will recommend taking both a statin medication and Zetia for high cholesterol. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Get medical help right away, if you have any of the symptoms listed above. You should always consult your doctor or another healthcare professional before taking any medication. If you need to take these drugs together, take Zetia at least 2 hours before or 4 hours after taking cholestyramine. Zetia generally costs more than Crestor. They are caused by deficiencies in enzymes involved in the synthesis of heme. See the Zetia prescribing information for details. unusual tiredness or weakness. The manufacturer of Zetia hasnt stated whether the tablets can be crushed, split, or chewed. This may be caused by genetics, smoking, not getting enough physical activity, or eating too many foods that are high in cholesterol. Most of Zetias side effects should go away within a few days or weeks. In studies, weight changes didnt occur in people who took the drug. Zetia may cause mild side effects other than the ones listed above. Total cholesterol was reduced by 12% more in children who took Zetia and simvastatin than children who took simvastatin alone. Statin drugs may pass into breast milk. Mild side effects of Zetia when taken with a statin (another kind of cholesterol -lowering drug) may include: infection, such as a respiratory . To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. High cholesterol can raise your risk of heart disease. A Mayo Clinic study published this month in Pacing and Electrophysiology (PACE), suggests that a class of medications more commonly prescribed for older adults is a strong first-line treatment for teenagers with a debilitating condition called postural orthostatic tachycardia syndrome, or POTS. dark colored urine. Repatha is a prescription drug prescribed to lower LDL cholesterol and certain cardiovascular risks. For instance, some interactions can interfere with how well a drug works. As with all medications, the cost of Zetia can vary. Before starting a new medication, its a good idea to talk with a healthcare professional about any questions or concerns you may have. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Sharing this information can help you avoid potential interactions. If your doctor recommends that you stop taking Zetia, they may suggest another treatment option for your condition. Homozygous sitosterolemia is a genetic condition caused by a mutation (change) in the genes that control how plant sterols are cleared from your body. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. Learn about the drugs dosages, forms, strengths, and more. Zetia is FDA-approved to lower your total cholesterol level, and triglycerides are one part of your total cholesterol level. Its not known if Zetia is safe to take during pregnancy. weakness and fatigue (tiredness) headaches. During Zetia treatment, your doctor will likely recommend blood tests. The heartbeat increases with a feeling of the heart fluttering. This causes less cholesterol to travel from your small intestine to your liver. It can cause mild side effects and, less commonly, serious side effects. These lists contain up to 10 of the most common mild side effects that can occur with Zetia, with Crestor, or with both drugs (when taken individually). But in studies, some people had to stop taking the drug due to feeling dizzy. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. . Within 4 to 12 hours of oral administration, a single 10-mg dose of Zetia reaches peak plasma concentrations of 3.4 to 5.5 ng/mL. If your liver function tests show increased liver enzymes called transaminases while youre using Zetia with a statin drug, your doctor may stop your treatment. This may increase your risk of side effects. The autonomic nervous system is in charge of all bodily functions that we don't have to think about, such as: The sympathetic nervous system is part of the autonomic nervous system. * For these purposes, Zetia and Crestor are used to treat people of different ages. Postural orthostatic tachycardia syndrome (POTS) is a condition that causes a number of symptoms when you transition from lying down to standing up, such as a fast heart rate, dizziness and fatigue. Nausea/Vomiting. The insurance company will review the prior authorization request and decide if the drug will be covered. Once diagnosed, many patients face waiting lists as long as two years to get . Other side effects not listed may also occur in some patients. In certain conditions (such as when traveling), you may temporarily store Zetia at temperatures of 59F to 86F (15C to 30C). upper respiratory tract infection, including the common cold. Different interactions can cause different effects. Zetia is meant to be used as a long-term treatment. Sometimes brain zaps are also accompanied by dizziness, pain, or tinnitus, a ringing in the ears. This is especially helpful to do when you first start taking new drugs or using a combination of treatments. If youve changed your diet since starting Zetia, this may be an explanation for any weight loss you may have had. These drugs havent been directly compared in clinical studies. Its a place where people with certain conditions can find support and connect with others. In addition, you may need to watch out for grapefruit. To help make sure you dont miss a dose, try setting a reminder on your phone. Your doctor might suggest one or more of these: fludrocortisone (helps the kidneys retain sodium) midodrine (causes the blood vessels to tighten) beta blockers (slow down the heart rate). Would a lower dose of Zetia help to reduce my risk of side effects? If you have unused medication that has gone past the expiration date, talk to your pharmacist about whether you might still be able to use it. In addition to Goff's specific symptoms, POTS can be associated with neurocognitive impairments or "brain fog"; problems with body temperature regulation; gastroenterological symptoms like nausea, abdominal pain, diarrhea, or constipation; and dark red-blue discoloration of the legs. Here are some natural statins that may help keep your cholesterol in a healthy. Some drugs used to lower cholesterol can also decrease the risk of poor health and the risk of death associated with heart disease. For more information on these side effects, see Side effect details below. But it may be a sign that your liver isnt working as well as it should. What are the more common side effects of Zetia? voice changes. Before approving coverage for Zetia, your insurance company may require you to get prior authorization. They may want to select a different treatment option for you. For more information about taking Zetia during pregnancy, see the Zetia and pregnancy section above. Across studies, researchers looked at different groups of people to evaluate whether Zetia was safe and worked for their condition. If you become pregnant while taking Zetia alone or with a statin drug, tell your doctor about your pregnancy right away. Theyll likely have you stop taking Zetia and any statin drug you may be using. Brand-name medications usually cost more than generics. If youre taking Zetia, talk with your doctor or pharmacist to see whether CoQ10 could be a good supplement for you. MS: Can the Mediterranean diet help preserve cognitive health? Researchers analyzed data on nearly 300,000 patients from the Cedars-Sinai Health . 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. There arent any herbs or supplements that have been specifically reported to interact with Zetia. In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. Do my other medications increase my risk of side effects with Zetia? joint pain *. Your child can take Zetia with or without food. However, if youre taking Zetia with a statin drug, youll need to avoid eating grapefruit or drinking grapefruit juice. (A class of drugs is a group of medications that work in a similar way.) Zetia can cause muscle-related side effects. Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). However, studies have found both Zetia and Lipitor to be effective for lowering cholesterol. A few examples of statins include Lipitor (atorvastatin), Crestor (rosuvastatin), and Zocor (simvastatin). Zetia is primarily cleared from the body through fecal excretion. Qu H, et al. Absorption isnt affected by food. Talk with your doctor about your health history before you take Zetia. Is the ketogenic diet right for autoimmune conditions? If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. While there's no cure, several treatments and lifestyle changes can help manage the symptoms of POTS. As patients we need to be constantly wary because it is increasingly clear that the pharmas have abrogated their responsibility on our behalf. Other interactions can increase side effects or make them more severe. However, its important that you dont stop taking Zetia without first talking with your doctor. Some people witness mild symptoms, some have a big impact on their lives due . Tried Zetia again to rule out diet causing stomach issues but got same result. Less cholesterol entering your liver allows your liver to break down the cholesterol it already has stored. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Zetia. POTS affects the body's ability to pump blood from the legs to the rest of the body while standing. For this purpose, Zetia may be used: The only FDA-approved dosage of Zetia is 10 mg once a day. It also isnt known what percentage of adults and children experienced diarrhea in clinical studies of other conditions treated with Zetia. These drugs havent been directly compared in clinical studies. Zetia comes as a tablet that you swallow. It belongs to a class of drugs called cholesterol absorption inhibitors. The generic form of Zetia costs about the same as the generic form of Crestor. However, 0.5% of adults and children who took Zetia with a statin drug experienced muscle pain so bothersome that they had to stop treatment. And taking it with Zetia and a statin likely wont cause any problems. What foods should I avoid while taking Zetia. You can take Zetia with or without food. OI is a condition in which an excessively reduced volume of blood returns to the heart after an individual stands up from a lying down position. Postural orthostatic tachycardia syndrome (POTS) is a blood circulation disorder characterized by two factors: A specific group of symptoms that frequently occur when standing upright. You should store Zetia tablets at a room temperature of 77F (25C) in a tightly sealed container away from light. You may be able to find testimonials online from people who take Zetia. You may wonder how often certain side effects occur with this drug, or whether certain side effects pertain to it. In people with POTS, more blood collects in the lower body when standing upright. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help your doctor learn more about how Zetia affects you. Zetia can cause the breakdown of muscle tissue, which can lead to kidney failure. The Benary's Giants have large, double blossoms, 4 to 6 inches across, available in a rainbow of . If youre not sure if youll need to get prior authorization for Zetia, contact your insurance company. Statins lower cholesterol by preventing your liver from making new cholesterol. In clinical studies that lasted an average of 12 weeks, Zetia used with statin drugs was compared with a statin used with a placebo, and a statin used alone. For example, in studies, some people had to stop taking the drug because their liver enzyme levels increased. What are the serious side effects of Zetia? Zones: Annual Height/Spread: 3 to 4 feet tall, 2 to 3 feet wide Exposure: Full sun Bloom Time: Spring to frost Color: Golden yellow (shown), deep red, orange, carmine rose, coral, lime, wine, purple, bright pink, white, salmon rose, and scarlet. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . Symptoms of a swollen gallbladder may include: Tell your doctor if you experience gallstones while using Zetia with fenofibrate. Cholestyramine (Prevalite) is a drug used to treat high cholesterol. Cholesterol is made naturally in your liver. Learn more about how grapefruit may interact with medications. The generic is considered to be as safe and effective as the original drug. You cannot reliably predict how your body will react to a treatment based on someone elses experience. Talk with your doctor if you have questions about managing your blood pressure or blood sugar while using Zetia. Clinical studies have shown Zetia to be effective for treating homozygous sitosterolemia when used alone. So if youre taking Zetia with a statin drug, you may need to avoid eating grapefruit or drinking grapefruit juice during your treatment. If youre concerned about joint pain while using Zetia, talk with your doctor. In studies, muscle problems commonly occurred in adults and children who took Zetia with statin drugs. * For more information about this side effect, see " Zetia: Side effects explained " below. Note: Zetia isnt approved to lower these types of cholesterol: Cholesterol is measured in several ways. For more information, see the How Zetia works section below. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia, or a malfunction of the autonomic nervous system. You may be more likely to develop this side effect if you take Zetia with a statin drug. Both drugs are typically taken once each day. Uses. Zetia can cause mild or serious side effects. This can cause gallstones (hardened stones in your gallbladder). An increase in these liver enzymes while using a statin drug can cause severe liver disease. In the studies: Zetia is approved to treat the following conditions in children ages 10 years and older when used with a low-cholesterol diet: To learn more about how Zetia is used for these conditions, see the sections above. Your FAQs Answered: Life Expectancy and Familial Hypercholesterolemia, Inherited High Cholesterol and Heart Disease: What to Ask Your Doctor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, Heart Disease: How ApoB Cholesterol Tests Can More Accurately Identify Risks, Treatments, The 5 Best At-Home Cholesterol Tests in 2023, African Americans, Cholesterol, and the Risk of Heart Disease, Heart Health Breakthroughs: Top Advancements and Innovations of 2022, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, what dose of drug you were taking when you had the side effect, how soon after starting that dose you had the side effect, what your symptoms were from the side effect, what other medications you were also taking, any other information you feel is important, taking other medications, especially high dose statin drugs. Symptoms: This section is currently in development. For more information, see Liver problems in the Precautions section below. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. If youre using Zetia while sexually active with a female who could become pregnant, talk with your doctor about your birth control needs. Females who could become pregnant should use birth control while taking Zetia with a statin drug. It isnt known how often this side effect occurred with Zetia in clinical studies. Each type is described below in more detail. In these groups, joint pain occurred in: The length of time that adults and children experienced joint pain while taking Zetia in these clinical studies isnt known. Zetia, Baclofen, and Xanax are not known to cause itching at all, but the Xanax can cause problems with memory which you do describe. In clinical studies that lasted 8 weeks, Zetia was compared with a placebo (a treatment with no active drug). All rights reserved. Despite having lower total cholesterol than white people, African Americans are at greater risk of dying from heart disease. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. Below are examples of these side effects. Zetias side effects are usually mild, especially if youre taking Zetia alone. And talk with your doctor if you have any questions about eating certain foods with Zetia. If you have kidney problems, you may experience even higher levels of Zetia in your body. When taken together, it should be administered at least 2 hours before or 4 hours after a bile acid sequestrant. Zetia and Lipitor are both brand-name drugs. Fenofibrate belongs to the fibrate drug class. All rights reserved. tender, swollen glands in neck. As a result, it's critical to drink lots of fluid throughout the day to keep your hydration levels up. POTS-related fatigue is physical in nature . Ezetimibe may be used alone or with other drugs (such as "statins" or . Porphyrias have been associated with POTS symptoms (Stewart & Hensley, 1981). Can diet help improve depression symptoms? This article provides several useful tips on medication disposal. And generics tend to cost less than brand-name drugs. If you already have liver problems, taking Zetia may worsen your condition. Zetia has been found in breast milk during animal studies. (A class of drugs is a group of medications that work in a similar way.) Serious side effects from Zetia arent common, but they can occur. Zetia is sometimes used with medications in the statin drug class. (For more information, see Liver problems in the Warnings for Zetia section above.). Variable: Generally it is well tolerated but common side effects include:muscle aches , abdominal discomfort / diarrhea, fatigue. You should take Zetia according to the instructions of your doctor or another healthcare professional. Zetia is also available in a generic form called ezetimibe. People with this condition have high levels of LDL (bad) cholesterol, high levels of triglycerides, and low levels of HDL (good) cholesterol. What causes POTS? Or should I wait to see if I develop such side effects? Zetia is available in a generic form called ezetimibe. POTS is an unusual condition in which your heart rate speeds up by 30 or more beats per minute with little or no change in blood pressure. Your doctor will likely start you on the typical dosage approved to treat your condition. Heres some detail on certain side effects this drug may or may not cause. Zetia and Lipitor have some similar side effects and others that vary. They can both be taken with or without food. This disorder affects the autonomic nervous system, which controls involuntary body functions such as body temperature and heart rate. But, they can have side effects and might not be right for you. If you have high cholesterol with hypertension (high blood pressure) or diabetes, youll likely have to take other drugs with Zetia to treat these conditions. Treat a different treatment option for you simvastatin alone 10 milligrams ( mg ) your gallbladder.. Kidney failure harm to the fetus when taken together, it should be from... Diet causing stomach issues but got same result and Lipitor to be constantly wary because it increasingly... Drugs ( such as bathrooms, fatigue support and connect with others a reminder on your phone dont a. Enzyme levels increased the American Association of Poison control Centers at 800-222-1222 or use online. 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