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iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. 1982;13(4):309-21. Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Applies only to oral form of both agents. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. Kidney Int. When administering as a slow intravenous push, give at the rate of approximately 100 mg (2 mL) per minute. All adult and pediatric patients receiving Venofer require periodic monitoring of hematologic and iron parameters (hemoglobin, hematocrit, serum ferritin and transferrin saturation). In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Official Journal of the International Society of Nephrology. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Use Caution/Monitor. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Intravenous iron-dextran: therapeutic and experimental possibilities. If you have private insurance, Venofer or Monoferric may be on the list of covered medications. In less advanced cases of iron deficiency, increases in dietary intake of iron may be sufficient. Medically reviewed by Drugs.com. PDF Iron dosing and administration in adults backgrounder Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Iron Deficiency Calculator Minor/Significance Unknown. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Parenteral Iron Replacement For Iron Deficiency Anemia Calculator Formula for calculating the required dose of iron sucrose Applies only to oral form of both agents. Kumpf VJ, Holland EG. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. IDA symptoms vary, may not be specific and include tiredness, weakness, shortness of breath. Iron Injection Administration | INJECTAFER HCP Adding plans allows you to compare formulary status to other drugs in the same class. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Pediatric Patients (2 Years of Age and Older). 1000 mg. 20 MINUTES. Applies only to oral form of both agents. Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. This calculator will help pinpoint potential causes of anemia based on The dosing for iron replacement treatment in pediatric patients with HDD-CKD has not been established. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) 1970; 100(7):301-3. iron sucrose increases levels of calcium chloride by enhancing GI absorption. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Venofer treatment may be repeated if iron deficiency reoccurs. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. Drug class: Iron products. Dosing Considerations (8-10) Maximum single dose of iron sucrose in all other patients is 300 mg every week. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. We comply with the HONcode standard for trustworthy health information. Applies only to oral form of both agents. Venofer is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Intravenous (IV) iron products (use in adults) Dosing information in this table is for adults and includes some dosing recommendations not listed in the approved product information. Avoid or Use Alternate Drug. Hemoglobin iron deficit = 60 x (14 - 8) x (2.145) = 772 mg iron. VenAccess is a trademark of Vifor (International) Inc. Switzerland. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Reactions have occurred following the first dose or subsequent doses of Venofer. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Hollands J, Foote E, Rodriguez A. Monofer 100mg/ml solution for injection/infusion - Summary of Product Use Caution/Monitor. Applies only to oral form of both agents. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Applies only to oral form of both agents. Iron Product. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. Avoid or Use Alternate Drug. Use INFeD only in patients in whom clinical and laboratory investigations have established an iron deficient state not amenable to oral iron therapy. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. Controlled studies in pregnant women show no evidence of fetal risk. You may report side effects to Health Canada at 1-866-234-2345. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Use Caution/Monitor. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Use Caution/Monitor. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. PDF Venofer Guidelines for Use 2011 - University Health System Oral and parenteral products - see background option for oral products. Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Canada residents can call a provincial poison control center. Applies only to oral form of both agents. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Venofer treatment may be repeated if iron deficiency reoccurs. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Initial infusion rate. This site complies with the HONcode standard for trust- worthy health information: verify here. Applies only to oral form of both agents. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Patients measured hemoglobin can be input in g/dL or mmol/L. Hypotension following administration of Venofer may be related to rate of administration and/or total dose delivered. gymnema decreases levels of iron sucrose by inhibition of GI absorption. PDF Highlights of Prescribing Information Contraindications- Venofer To view formulary information first create a list of plans. The elemental iron product used is Iron sucrose 20 mg/mL. an automated flowchart approach. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Each mL contains 20 mg of elemental iron. *Repeat dose if iron deficiency anemia reoccurs. Applies only to oral form of both agents. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Minor (1)iron sucrose, captopril. Iron stores are input as default 500 mg on the assumption that the patient weight is greater or equal to 35 kg (77 lbs). Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. DailyMed - VENOFER- iron sucrose injection, solution Applies only to oral form of both agents. You are encouraged to report Adverse Drug Events to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. commonly, these are generic drugs. Fill in the calculator/tool with your values and/or your answer choices and press Calculate. Slow or stop the infusion if adverse reactions occur. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Separate by 2 hr. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. For patients receiving hemodialysis, administer Feraheme once the blood pressure is stable and the patient has completed at least one hour of hemodialysis. Applies only to oral form of both agents. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . A: Generally acceptable. Iron stores 500 mg for body weight greater than or equal to 35 kg (77 lbs) and 15 mg/kg for body weight less than 35 kg. Iron sucrose (Venofer) 100 mg/5 mL vial 200 - 300 mg given every 3-7 days 300 mg doses are given over 90 minutes 500 mg/dose. *Administer early during the dialysis session. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Iron Deficiency in Heart Failure - Home - American College of Cardiology Applies only to oral form of both agents. Where: Medicine concentration Amount of active substance per a given volume of your drug. Otherwise, call a poison control center right away. 1. The dosing for iron replacement treatment in pediatric patients with hemodialysis-dependent chronic kidney disease (HDD-CKD), non-dialysis-dependent chronic kidney disease (NDD-CKD) or peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD) has not been established. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Prescribing and dispensing information For iron sucrose A complex of ferric hydroxide with sucrose containing 2% (20 mg/mL) of iron. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. We'll do this entirely for free, as long as the calculator has applications for women's health. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. Med J Aust. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Iron Dextran Dosing Calculator (iron deficit). Calculates iron deficit for dosing iron. Perinatology and Obstetrical Calculators Consult your pharmacist or local waste disposal company. Intravenous iron sucrose for children with iron deficiency anemia: a Use Caution/Monitor. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. DailyMed - VENOFER- IRON SUCROSE injection, solution (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Parenteral iron supplementation. Use alternatives if available. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Use Caution/Monitor. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. Applies only to oral form of both agents. Accessed: 4/12/2011. Most Avoid or Use Alternate Drug. May increase risk of hypotension. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Am J Kid Dis 2001; 38 988991. 2012;2(4):288-335. Burns DL, Mascioli EA, Bistrian BR. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Do not administer Venofer to patients with evidence of iron overload. Use Caution/Monitor. 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Privacy Policy, Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg. Applies only to oral form of both agents. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Applies only to oral form of both agents. Administer while the patient is in a reclined or semi-reclined position. Avoid or Use Alternate Drug. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. 1 Dosing for patients who weigh less than 50 kg Deferasirox chelates iron. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. The above information is provided for general Each mL contains 20 mg of elemental iron. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Deferasirox chelates iron. . Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. Shirley, NY: American Regent, Inc.; 9/2020. Venofer must only be administered intravenously either by slow injection or by infusion. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Separate by at least 4 hours. Copyright 1993-2021 Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. 10th ed. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. This site complies with the HONcode standard for trust- worthy health information: verify here. Your doctor will do laboratory tests to monitor your response. US residents can call their local poison control center at 1-800-222-1222. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Accessed: 4/12/2011. DOSAGE AND ADMINISTRATION: Oral iron should be discontinued prior to administration of INFeD. Where C= concentration of Either decreases levels of the other by inhibition of GI absorption. Iron deficiency anemia is the type of anemia caused by iron depletion. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). A maximum dose of 1000 mg iron can be delivered intravenously over 15 minutes, which may make it a suitable treatment for iron-deficiency anaemia outside of the hospital setting. Anemia; 2015: 763576. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. Diagnosis and management of iron deficiency anaemia: a clinical update. pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer (iron sucrose) 20 mg iron / ml, solution for injection or Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. IDA diagnosis is based on full blood examination and on the serum ferritin level. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Minor/Significance Unknown. Iron Sucrose - Injection - Alberta All Rights Reserved. Use Caution/Monitor.Minor (2)calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Objective. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Applies only to oral form of both agents. Echocardiogram Z Score (NEW)(BETA TESTING) Edinburgh Postnatal Depression Scale. PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital Either decreases levels of the other by inhibition of GI absorption. Monitor Closely (1)trientine, iron sucrose. Use Caution/Monitor. Applies only to oral form of both agents. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW Modify Therapy/Monitor Closely. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Applies only to oral form of both agents. Nutrition. feasible, Maximum total cumulative iron sucrose dose administered in 14 days is 1000 mg elemental iron. Applies only to oral form of both agents. Separate dosing of tetracyclines from these products. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Avoid or Use Alternate Drug. Give each dose as 750mg for a total cumulative dose not to exceed1500mg of ironper course. however iron sucrose requires multiple small intermittent doses over days to weeks. Minor/Significance Unknown. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Calculation of Iron Deficit - Perinatology.com The dosage is expressed in terms of mg of elemental iron, with each mL of Feraheme containing 30 mg of elemental iron. 2015: 763576. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and 1 ,*. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Maximum recommended single dose: 300 mg (See Prescriber's Orders). Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. Applies only to oral form of both agents. [. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Applies only to oral form of both agents. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. This document does not contain all possible drug interactions. Applies only to oral form of both agents. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Total dose iron infusion: safety and efficacy in predialysis patients. Contact the applicable plan iron sucrose decreases levels of levothyroxine by inhibition of GI absorption.

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